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KMID : 1130620140100030262
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Journal of Clinical Neurology
2014 Volume.10 No. 3 p.262 ~ p.266
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Anti-Ma2 Paraneoplastic Encephalitis in Association with Recurrent Cervical Cancer
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Ney Douglas E
Messersmith Wells
Behbakht Kian
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Abstract
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Background: Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy.
Case Report: We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes.
Conclusions: This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy.
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KEYWORD
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paraneoplastic syndromes, cervical cancer, anti-Ma2 encephalitis
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